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- Table of Contents
CDKN2A Antibodies
AND CDKN2A ELISA kits, CDKN2A Proteins
Many biological assays use antibodies to detect CDKN2A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CDKN2A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CDKN2A antibodies...
Designing an IHC experiment for CDKN2A? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the CDKN2A IHC GuideCDKN2A Infographic by Boster Bio
All CDKN2A Products
Product
Figures
Specificity
Applications
Price
Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A05786-1
100 μg/vial
Cat # A05786-1
100 μg/vial
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00016
100 μl
Cat # M00016
100 μl
Human
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # M00016-2
100 μl/vial
Cat # M00016-2
100 μl/vial
Human, Mouse, Rat
ELISA, IF, IHC-P, WB
$481
Cat # A00016-1
0.1 mg
Cat # A00016-1
0.1 mg
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # A00016-5
100 μl/vial
Cat # A00016-5
100 μl/vial
Human
ELISA, IP, IF, WB
$146
Cat # M00016-3
20μL, 40μL, 100μL, 200μL
Cat # M00016-3
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA, IP, IF, WB
$146
Cat # M00016-4
20μL, 40μL, 100μL, 200μL
Cat # M00016-4
20μL, 40μL, 100μL, 200μL
Human, Mouse
ELISA
$480
Cat # EKC1417
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1417
1 kit, containing one 96-well plate and all necessary reagents
Human
IF, IHC, ICC, WB
$370
Cat # M00016-5
100 μl/vial
Cat # M00016-5
100 μl/vial
CDKN2A Overview
Facts about Cyclin-dependent kinase inhibitor 2A.
Cyclin-dependent kinase inhibitor 2A (CDKN2A)
Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | CDKN2A |
| Uniprot: | P42771 |
| Entrez: | 1029 |
Family
| Belongs to: |
|---|
| CDKN2 cyclin-dependent kinase inhibitor family |
Alternative Names
alternative reading frame; ARF; ARF-INK4a; CDK4I; CDKN2A; Cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A, isoform 3; cyclin-dependent kinase inhibitor 2A, isoforms 1/2; cyclin-dependent kinase inhibitor protein; INK4; INK4a; Ink4a/Arf; INK4a-ARF; mitochondrial smARF'; MTS1; p14; p14ARF; P16; p16(INK4a); p16-INK4; P16INK4A; p16-INK4a; P19; p19<ARF>; p19ARF; Pctr1
Molecular Weight
Mass (kDA):
16.533 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9p21.3 |
| Sequence: | 9; NC_000009.12 (21967752..21995324, complement) |
Tissue Specificity
Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific.
Subcellular Localizations
Cytoplasm. Nucleus.
Diseases
- Melanoma, cutaneous malignant 2 (CMM2)
Interacting Proteins
- CDK4
- CDK6
- CRELD2
- DEAF1
- HNRNPU
- MCM6
- PCNA
- TDRD7
PTMs
- Acetylation
Research Areas
- ABC Transporters
- Biologically Active Proteins
- DNA Repair
- Hypoxia
- MAP Kinase Signaling
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CDKN2A
bosterbio.com/bosterbio-gene-info-cards/CDKN2A
References
PMID: 8259215 by Serrano M., et al. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.
PMID: 10445844 by Robertson K.D., et al. Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus.
4 Publications of Boster CDKN2A Antibodies & ELISA Kits
- PubMed ID: 10.1038/s41419-020-2238-1, P53 and Parkin co-regulate mitophagy in bone marrow mesenchymal stem cells to pr...
- PubMed ID: 15378766, Construction of pETNF-P16 plasmid and its expression properties in EC9706 cell l...
- PubMed ID: 30070315, Expression of p16 protein in infantile hemangioma
- PubMed ID: 22228178, Song Lj, Liu Rj, Zeng Z, Alper Sl, Cui Hj, Lu Y, Zheng L, Yan Zw, Fu Gh. J Mol M...
*More publications can be found for each product on its corresponding product page